Effects of Zinc Supplementation and Deficiency on Bone Metabolism and Related Gene Expression in Rat |
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| Authors: | Jian-Yi Sun Jian-Feng Wang Nai-Tao Zi Ming-Yan Jing Xiao-Yan Weng |
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| Institution: | (1) The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Science, Zhejiang University, Hangzhou, People’s Republic of China;(2) Zhejiang Radio and TV University, Hangzhou, People’s Republic of China;(3) College of Life Science, Zhejiang University, Hangzhou, People’s Republic of China;(4) Present address: Department of Animal Science, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada; |
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| Abstract: | One hundred male rats were randomly divided into four groups (n = 25) and fed a Zn-adequate diet (ZA, 46.39 mg/kg), Zn-deficient diet (ZD, 3.20 mg/kg), Zn-overdose diet (ZO, 234.39 mg/kg),
or were pair-fed a Zn-adequate diet (PF) for 5 weeks, respectively. The body weight, femur weight, and activity of alkaline
phosphatase (ALP) were reduced in the ZD group but were increased in the ZO group. Zn concentrations in both liver and femur
were elevated in the ZO group, whereas femur Zn was decreased in the ZD group. The concentrations of calcium and phosphorus
were lower in the ZD than those in other groups. Serum calcium concentration was decreased in the ZD. The relative expression
level of ALP was decreased in both ZD and PF, and no significant differences were observed between ZO and ZA. Insulin-like
growth factor-I (IGF-I) mRNA level was reduced in the ZD but unchanged in the ZO and PF group. Zn deficiency also decreased
ALP mRNA level as compared with that of PF group. Carbonic anhydrase II mRNA level was not affected by Zn. Nevertheless, dietary
Zn influenced the growth, bone metabolism, and expression of IGF-I and ALP in male growing rats. |
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