Deciphering the molecular and physiological connections between obesity and breast cancer |
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| Authors: | Zhao He Andy B. Chen Gen-Sheng Feng |
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| Affiliation: | 1. Department of Pathology, School of Medicine, and Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA, 92093-0864, USA
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| Abstract: | Obesity is associated with the higher risk of breast cancer in postmenopausal women. The leptin signaling pathway is recognized to primarily regulate energy balance and associated with breast cancer. Furthermore, the estrogen signaling pathway plays a critical role in breast carcinogenesis. In this review, we discuss how obesity is linked to breast cancer via cross-talk of leptin and estrogen pathways. |
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