From spikers to bursters via coupling: Help from heterogeneity |
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Authors: | Gerda de Vries Arthur Sherman |
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Institution: | (1) Department of Mathematical Sciences, University of Alberta, Edmonton, AB, T6G 2G1, Canada;(2) Mathematical Research Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA |
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Abstract: | It has been shown previously that identical spiking cells, incapable of bursting by themselves, may burst under weak diffusive
coupling conditions. With stronger coupling, the coupled system reverts to bursting can be recovered by introducing heterogeneity
in the model parameters. For a two-cell system, we explain the phenomenon with bifurcation analysis. For larger clusters of
coupled cells, we demonstrate by numerical simulation that the phenomenon carries over. In addition, we use a perturbation
analysis to deduce the dependence of the heterogeneity parameter used in the bifurcation analysis on the original heterogeneity
parameters and the coupling strength. Implications of the phenomenon of emergent bursting are discussed in the context of
electrical activity in pancreatic beta cells. |
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Keywords: | |
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