Emerging roles of transforming growth factor β signaling in wet age-related macular degeneration |
| |
作者姓名: | Kai Wang Haoran Li Ruipu Sun Chaxian Liu Yunfei Luo Shuhua Fu Ying Ying |
| |
作者单位: | Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology and Department of Pathology;Nanchang Joint Program;The Second Clinical Department;Department of Pathophysiology;Department of Ophthalmology |
| |
基金项目: | the grants from the National Natural Science Foundation of China (Nos.81660163 and 81560299);the Science and Technology Foundation of Jiangxi Province (Nos.20142BAB215053 and 2015BBG70171);the Foundation of the Second Affiliated Hospital of Nanchang University (No.2016YNZJ12001). |
| |
摘 要: | Age-related macular degeneration (AMD) is one of the major causes of irreversible blindness among aging populations in developed countries and can be classified as dry or wet according to its progression.Wet AMD,which is characterized by angiogenesis on the choroidal membrane,is uncommonly seen but more severe.Controlling or completely inhibiting the factors that contribute to the progression of events that lead to angiogenesis may be an effective strategy for treating wet AMD.Emerging evidence has shown that transforming growth factor-β(TGF-β) signaling plays a significant role in the progression of wet AMD.In this review,we described the roles of and changes in TGF-β signaling in the development of AMD and discussed the mechanisms of the TGF-β superfamily in choroidal neovascularization (CNV) and wet AMD,including the modulation of angiogenesis-related factors,inflammation,vascular fibrosis,and immune responses,as well as cross-talk with other signaling pathways.These remarkable findings indicate that TGF-β signaling is a potential target for wet AMD treatment.
|
关 键 词: | TGF-β SUPERFAMILY WET AMD ANGIOGENESIS |
本文献已被 维普 等数据库收录! |