Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis |
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Authors: | Email author" target="_blank">Jon?T?GilesEmail author Ver?nica?Fernandes Joao?AC?Lima Joan?M?Bathon |
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Institution: | (1) Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;(2) Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA |
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Abstract: | Data from population- and clinic-based epidemiologic studies of rheumatoid arthritis patients suggest that individuals with
rheumatoid arthritis are at risk for developing clinically evident congestive heart failure. Many established risk factors
for congestive heart failure are over-represented in rheumatoid arthritis and likely account for some of the increased risk
observed. In particular, data from animal models of cytokine-induced congestive heart failure have implicated the same inflammatory
cytokines produced in abundance by rheumatoid synovium as the driving force behind maladaptive processes in the myocardium
leading to congestive heart failure. At present, however, the direct effects of inflammatory cytokines (and rheumatoid arthritis
therapies) on the myocardia of rheumatoid arthritis patients are incompletely understood. |
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Keywords: | |
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