X-chromosome inactivation: X marks the spot for BRCA1 |
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| Authors: | Stone Caroline McCabe Nuala Ashworth Alan |
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| Institution: | The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, SW3 6JB, London, UK. |
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| Abstract: | X-chromosome inactivation equalizes the dosage of X-linked genes in XX females with that in XY males. Recent findings reveal that the BRCA1 breast cancer susceptibility gene has an important function in this epigenetic phenomenon. |
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