Selective and effective cleavage of RNAs by vinyladenine-vinylamine copolymer. |
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| Authors: | T Shiiba M Komiyama E Yashima M Akashi |
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| Institution: | Institute of Material Science, University of Tsukuba, Ibaraki, Japan. |
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| Abstract: | Poly(uridylic acid) (polyU]) and poly(adenylic acid) (polyA]) are efficiently cleaved, via phosphodiester linkage hydrolysis, at pH 8, 50 degrees C by use of poly(vinyladenine-co-vinylamine) as catalyst. The catalytic activity of the copolymer surpasses the value of poly(vinylamine), indicating a significant role of the adenine residue in the copolymer for the effective catalysis. |
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