The identification of two novel prostaglandins and a thromboxane |
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| Authors: | Anthony F Cockerill David NB Mallen David J Osborne John R Boot William Dawson |
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| Institution: | Physical Organic Research, Lilly Research Centre Limited, Erl Wood Manor, Windlesham, Surrey, England;Pharmacology Research, Lilly Research Centre Limited, Erl Wood Manor, Windlesham, Surrey, England |
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| Abstract: | 6,15-Dioxo-PGF1α, 6-15-dioxo-13,14-dihydro-PGF1α and 15-oxo-thromboxane B2 have been identified in incubates of ram seminal vesicle homogenates with added arachidonic acid or in the perfusate from sensitised challenged guinea pig lungs. These compounds are probably related to 6-oxo-PGF1α and thromboxane B2. The structures have been determined by gas chromatography mass spectrometry, following suitable chemical derivatisation. |
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