| 热休克蛋白27在肿瘤中的研究进展 |
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| 引用本文： | 周莉娜,向江东.热休克蛋白27在肿瘤中的研究进展[J].生物磁学,2011(1):198-200. |
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| 作者姓名： | 周莉娜 向江东 |
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| 作者单位： | [1]同济大学附属第一妇婴保健院,上海200040 [2]上海交通大学附属第一人民医院,上海200080 |
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| 摘 要： | 热休克蛋白27（HSP27）作为热应激蛋白表达于各种生理或是环境损伤之后,保护细胞生存,其具有多种功能包括：分子伴侣,抗凋亡,参与细胞运动等。近年来发现HSP27在多种肿瘤中过度表达,参与肿瘤的发生发展,分化,耐药以及转移等方面,因而抑制HSP27成为一种新的肿瘤治疗策略。本文就相关研究进展进行综述。
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| 关 键 词： | HSP27 肿瘤 耐药 转移 |
Progress of heat shock protein 27 in Tumors |
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| ZHOU Li-na△,XIANG Jiang-dong.Progress of heat shock protein 27 in Tumors[J].Biomagnetism,2011(1):198-200. |
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| Authors: | ZHOU Li-na△ XIANG Jiang-dong |
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| Institution: | 1 Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine,Shanghai,200040,China; 2 Shanghai Jiao Tong University Affiliated Fist People＇s Hospital,Shanghai,200080,China) |
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| Abstract: | Heat shock protein 27（HSP27） is expressed in response to a large amount of physiological and environmental insults,thus allowing the cell to survive in lethal conditions.HSP27 has complex activities such as molecular chaperones,anti-apoptosis and in-duce cell movement.Recently,many researches have found that HSP27 is over-expressed in various tumors,it plays a important role in tumorigenesis,progress,differentiation,metastasis and chemotherapy resistance.Therefore,the inhibition of HSP27 has become a novel strategy of cancer therapy.Herein we reviewed the progress of relevant researches. |
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| Keywords: | Heat shock protein 27 Tumor Drug Resistance Metastasis |
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