GSTP1、E-cadherin在垂体腺瘤中的表达及临床意义

目的：研究谷胱甘肽S-转移酶P1（GSTP1）、上皮钙粘蛋白（E-cadherin）在垂体腺瘤中的表达及临床意义。方法：应用免疫组化SP染色法检测30例侵袭性垂体腺瘤与30例非侵袭性垂体腺瘤中GSTP1、E-cadherin的表达。结果：GSTP1在侵袭性垂体腺瘤中的表达较非侵袭性垂体腺瘤显著降低（P〈0.05）;E-cadherin在侵袭性垂体腺瘤中的表达较非侵袭性垂体腺瘤显著降低（P〈0.05）;GSTP1、E-cadherin在垂体腺瘤中的表达呈正相关（r=0.82,P〈0.05）。结论：GSTP1、E-cadherin在垂体腺瘤中的表达与肿瘤侵袭程度显著相关,两者联合检测有助于判断垂体腺瘤侵袭性及预后。

Expressions of GSTP1 and E-cadherin in Pituitary Adenomas and Their Clinical Features

Objective： To investigate the expressions of Glutathione S-transferases P1（GSTP1） and E-cadherin in pituitary adenomas and analyze their clinical significance.Methods： The SP immunohistochemical method was used to detect the expressions of GSTP1 and E-cadherin in 30 invasive pituitary adenomas and 30 noninvasive pituitary adenomas.Results： Expression of GSTP1 was significantly lower in invasive pituitary adenomas than in noninvasive pituitary adenomas（P0.05）;expression of E-cadherin protein was significantly lower in invasive pituitary adenomas than in noninvasive pituitary adenomas（P0.05）;expression of GSTP1 has positive correlation with the expression of E-cadherin in pituitary adenomas（r=0.82,P0.05）.Conclusions： The expressions of GSTP1 and E-cadherin are closely correlated with aggressive pituitary adenoma behavior,which are helpful for the evaluation of tumor invasion and prognosis.