近红外光谱技术在猫脑射频热凝毁损中的应用研究

目的：探索近红外光谱（nears）技术用于立体定向靶点毁损术中实时监测的可行性。方法：利用猫脑建立体内不同毁损时间、温度下的毁损灶体积模型,通过病理检测及近红外光谱仪观察并记录脑组织靶点毁损时的NIRS尤其是优化散射系数（）的变化情况。结果：不同温度、不同时间温度点下NIRS出现特征性变化曲线。并建立时间、温度及三维模型。结论：利用NIRS实时活体在位监测猫脑射频神经核团毁损术是科学、可行的,优化散射系数是监测的良好指标,比以往单凭经验的作法更科学、更准确。

Application of near-infrared spectroscopy technology in cat brain radiofrequency

Objective： To investigate the feasibility of near-infrared spectroscopy（NIRS） technology i monitor real-time target in the stereotactic destruction technology.Methods： In vivo volume models of RF lesion with different lesion time and temperature were es-tablished（,adult cats in vivo）.The height and maximum lesion diameter of adult cats in vivo were detected by pathology testing and MRI.Target destruction in near-infrared spectroscopy monitoring： Changes in brain tissue,the changes of reduced scattering coefficient in particular,were detected by brain tissue spectroscopy.Results： Under the same lesion conditions,there was significant difference be-tween the volume of in vivo（p0.05）,the volume which obtained frome in vivo was alerted regularly by the changes of the lesion time and lesion temperature.Conclusion： Real-time near infrared technology in vivo to monitor RF power in damaged nucleus of cats was sci-entific and feasible.In addition,the reduced scattering coefficient was good indicator for monitoring.