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近红外光谱技术在猫脑射频热凝毁损中的应用研究
引用本文:张立国,杨天明,钱志余,潇笛,郭凯,刘华亭. 近红外光谱技术在猫脑射频热凝毁损中的应用研究[J]. 生物磁学, 2011, 0(1): 71-74
作者姓名:张立国  杨天明  钱志余  潇笛  郭凯  刘华亭
作者单位:[1]东南大学附属中大医院神经外科,江苏南京210009 [2]南京航空航天大学生物医学工程系,江苏南京210016
基金项目:国家高技术研究863计划基金资助(2008AA02Z438)
摘    要:目的:探索近红外光谱(nears)技术用于立体定向靶点毁损术中实时监测的可行性。方法:利用猫脑建立体内不同毁损时间、温度下的毁损灶体积模型,通过病理检测及近红外光谱仪观察并记录脑组织靶点毁损时的NIRS尤其是优化散射系数()的变化情况。结果:不同温度、不同时间温度点下NIRS出现特征性变化曲线。并建立时间、温度及三维模型。结论:利用NIRS实时活体在位监测猫脑射频神经核团毁损术是科学、可行的,优化散射系数是监测的良好指标,比以往单凭经验的作法更科学、更准确。

关 键 词:近红外光谱技术  优化散射系数  立体定位技术  猫脑

Application of near-infrared spectroscopy technology in cat brain radiofrequency
ZHANG Li-guo,YANG Tian-ming△,QIAN Zhi-yu,XIAO Di,GUO Kai,LIU Hua-ting. Application of near-infrared spectroscopy technology in cat brain radiofrequency[J]. Biomagnetism, 2011, 0(1): 71-74
Authors:ZHANG Li-guo  YANG Tian-ming△  QIAN Zhi-yu  XIAO Di  GUO Kai  LIU Hua-ting
Affiliation:1 Department of Neurosurgery,Zhongda Hospital,Southeast University,Nanjing 210009,China; 2 Department of Biomedical Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China)
Abstract:Objective: To investigate the feasibility of near-infrared spectroscopy(NIRS) technology i monitor real-time target in the stereotactic destruction technology.Methods: In vivo volume models of RF lesion with different lesion time and temperature were es-tablished(,adult cats in vivo).The height and maximum lesion diameter of adult cats in vivo were detected by pathology testing and MRI.Target destruction in near-infrared spectroscopy monitoring: Changes in brain tissue,the changes of reduced scattering coefficient in particular,were detected by brain tissue spectroscopy.Results: Under the same lesion conditions,there was significant difference be-tween the volume of in vivo(p0.05),the volume which obtained frome in vivo was alerted regularly by the changes of the lesion time and lesion temperature.Conclusion: Real-time near infrared technology in vivo to monitor RF power in damaged nucleus of cats was sci-entific and feasible.In addition,the reduced scattering coefficient was good indicator for monitoring.
Keywords:Near-infra red spectroscopy  Reduced scattering coefficient  Stereotactic technology  Cats
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