不同液体复苏对失血性休克大鼠肠粘膜的影响

目的：观察不同液体复苏对失血性休克大鼠肠粘膜的影响以及肠粘膜的变化。方法：利用大鼠失血性休克模型以及不同的补液方式,在复苏后120分钟时处死大鼠,取回肠4cm,做病理切片并根据Chiu等方法评估回肠黏膜上皮损伤指数。结果：液体复苏组的肠粘膜损伤程度小于休克不补液组（p〈0.05）,而限制型液体复苏组的肠粘膜损伤程度小于充分液体复苏组（p〈0.05）。结论：通过本实验对肠粘膜的观察可以得出,对于失血性休克,液体复苏时有效的抗休克方式,而对于复苏的方式来说,从肠黏膜的保护方面来说,限制型液体复苏是优于传统的充分液体复苏的。

Effect of different fluid resuscitation on intestinal mucosa in rats with hemorrhagic shock

Objective：To observe different fluid resuscitation of uncontrolled hemorrhagic shock rats intestinal mucosa and influ-ence of bowel mucosa changes.Methods：By using rat uncontrolled hemorrhagic shock model and different rehydration ways,the rats were killed 120 minutes after recovery,taking the ileum 4 cm,doing pathological and according to the methods of assessment Chiu ileum mu-cosal surfaces damage index.Results：fluid resuscitation group intestinal mucosa damage degree of less than shock not rehydration group（p 0.05）,and restricted type fluid resuscitation group intestinal mucosa damage degree of less than large amounts of fluid resusci-tation group（p 0.05）.Conclusion：through the experiment of bowel mucosa observations can be concluded that the fluid resuscitation for uncontrolled hemorrhagic shock,when effective way,but for resistance to shock recovery way,restricted type fluid resuscitation is superior to the traditional fully fluid resuscitation.