阿司匹林对癫痫大鼠海马苔藓纤维芽生的影响

目的：探讨阿司匹林对癫痫大鼠海马齿状回苔藓纤维芽生的影响。方法：应用氯化锂-匹罗卡品诱导癫痫大鼠模型,将大鼠随机分为正常对照组、模型组和阿司匹林（20mg/kg,i.p.1/d）干预组（造模终止后干预组以开始干预时间点的不同分为0h,3h和24 h三组）。20天后,通过Timm染色观察不同时间点阿司匹林干预后癫痫大鼠海马齿状回苔藓纤维芽生的情况。结果：与正常对照组相比,癫痫大鼠海马齿状回有明显的苔藓纤维芽生（P〈0.05）。阿司匹林0h干预组海马齿状回苔藓纤维芽生减少不明显（P〉0.05）,3h干预组和24h干预组海马齿状回苔藓纤维芽生明显的减少（P〈0.05）;3 h干预组和24 h干预组相比海马齿状回苔藓纤维芽生无明显的差异（P〉0.05）。结论：合适的时间窗给予阿司匹林能够明显减少苔藓纤维芽生。这对癫痫的临床治疗有一定的指导意义。

Effects of Aspirin on Mossy Fiber Sprouting in Hippocampus of Epileptic Rats

Objective：To explore the effects of aspirin on mossy fiber sprouting（MFS） in hippocampal dentate gyrus（DG） of epileptic rats.Methods Lithium-pilocarpin was used to induce epilepsy model of rats.The rats were randomly and equally divided into control group,epileptic group and aspirin group（20 mg/kg,i.p.1/d）.In building mode terminated,the aspirin group divided into 0 h,3 h and 24 h three groups by different time points of start intervention.After 20 days,Timm histochemistry was used to observe the hippocampal DG MFS.Results Compared with control group,A significant difference was found in epileptic rats（P〈0.05）.20-day aspirin treatment could decrease the MFS in hippocampal DG at 3 h and 24 h group（P〈0.05） but not at 0h group（P〉0.05）.There was no statisti-cal difference between 3 h aspirin group and 24 h aspirin group.Conclusions：Aspirin administrated at suitably time windows can decrease MFS significantly.These results suggest potential new targets for antiepileptic therapy.