| 冠心病患者低密度脂蛋白与血小板GMP-140水平相关性研究 |
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| 引用本文： | 高珊,刘克坚,邱癌.冠心病患者低密度脂蛋白与血小板GMP-140水平相关性研究[J].生物磁学,2011(3):552-554. |
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| 作者姓名： | 高珊 刘克坚 邱癌 |
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| 作者单位： | [1]石河子大学医学院,新疆石河子832000 [2]石河子大学医学院第一附属医院心内一科,中国新疆石河子832000 |
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| 摘 要： | 目的：探讨冠心病患者低密度脂蛋白与血小板功能活化产物GMP-140的关系。方法：应用酶联免疫分析法对120例研究对象进行了血浆LDL、GMP-140水平的测定,其中包括急性冠脉综合征组40例,稳定性心绞痛组40例,并与40例正常健康人作比较。结果：ACS患者血浆LDL和GMP-140水平均非常显著的高于正常人组（P〈0.01）,ACS组又高于SAP组（P〈0.05）,且血浆LDL与GMP-140水平呈正相关。结论：检测CHD患者血浆LDL和GMP-140水平的变化对CHD的发生和发展以及疗效和预后观察均具有重要的临床意义。
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| 关 键 词： | 冠心病 低密度脂蛋白 血浆α颗粒膜蛋白-140 |
Correlation of Low Density Lipoprotein Cholesterol and GMP-140 in Patients with Coronary Heart Disease |
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| Institution: | GAO Shan,LIU Ke-jian,QIU Qiang(1 The medical college of Shihezi University,Shihezi,Xinjiang Uygur Autonomous Region,832000,China; 2 Department of Cardiology,first affiliated hospital of the medical college,Shihezi University,Shihezi,Xinjiang Uygur Autonomous Region,832000,China) |
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| Abstract: | Objective：To study the correlation between LDL and GMP-140 in Coronary Heart Disease.Methods：LDL and GMP-140 levels（with ELISA） were determined in 80 patients with CHD（40 ACS,40SAP） and 40 controls.Results：LDL and GMP-140 levels in patients with CHD were significantly higher than those in controls（P0.01）.Among the CHD patients,magnitude of changes of the levels of LDL and GMP-140 in ACS groups were larger than those in SAP groups（P0.05）.LDL levels were positively correlated with GMP-140 levels.Conclusion：The LDL and GMP-140 levels were closely related to the diseases process of CHD and were of great clinical importance. |
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| Keywords: | coronary heart diseases low density lipoprotein cholesterol granular membranous protein |
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