Assessment of evidence for a protective role of vitamin D in multiple sclerosis |
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| Authors: | Heather EC Hanwell Brenda Banwell |
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| Institution: | a Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canadab Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canadac Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canadad Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada |
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| Abstract: | Evidence for a role of vitamin D insufficiency in determining risk in Multiple Sclerosis (MS) is supported by studies in both pediatric- and adult-onset patients. The potential role of vitamin D in modulating MS disease activity is an area of active clinical trials research, and the possibility of primary disease prevention with vitamin D supplementation in early life is an emerging concept. With Sir Austin Bradford Hill's criteria as a framework, the present review assesses the evidence for a causal relationship between vitamin D insufficiency and the pathobiology of MS, and discusses rationale for future clinical trials with vitamin D. |
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| Keywords: | Vitamin D Multiple Sclerosis Hill's Criteria |
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