Structures and biological functions of IL-31 and IL-31 receptors |
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| Authors: | Zhang Qing Putheti Prabhakar Zhou Qiang Liu Quansheng Gao Wenda |
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| Institution: | aDivision of Medical Cell Biology, College of Life Sciences, Sichuan University, 29 Wangjiang Road, Chengdu 610041, PR China;bDepartment of Medicine, Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA |
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| Abstract: | Interleukin-31, produced mainly by activated CD4+ T cells, is a newly discovered member of the gp130/IL-6 cytokine family. Unlike all the other family members, IL-31 does not engage gp130. Its receptor heterodimer consists of a unique gp130-like receptor chain IL-31RA, and the receptor subunit OSMRβ that is shared with another family member oncostatin M (OSM). Binding of IL-31 to its receptor activates Jak/STAT, PI3K/AKT and MAPK pathways. IL-31 acts on a broad range of immune- and non-immune cells and therefore possesses potential pleiotropic physiological functions, including regulating hematopoiesis and immune response, causing inflammatory bowel disease, airway hypersensitivity and dermatitis. This review summarizes the recent findings on the biological characterization and physiological roles of IL-31 and its receptors. |
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| Keywords: | IL-31 Receptors Biological function Immunological regulation |
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