Localization of immunoreactive tissue kallikrein in the seromucous glands of the human and guinea-pig respiratory tree |
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| Authors: | M. T. Poblete G. Garces C. D. Figueroa K. D. Bhoola |
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| Affiliation: | (1) Department of Pathology, National Health Service, J. F. Kennedy Hospital, Chile;(2) Institute of Histology Pathology Austral University, Valdivia, Chile;(3) Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol, UK;(4) Department of Experimental and Clinical Pharmacology, Medical School, University of Natal, 4013 Durban, Congella, South Africa;(5) The Medical School, University of Natal, South Africa |
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| Abstract: | Summary An immunocytochemical study focused on the cellular localization of tissue kallikrein along the human and guinea-pig respiratory tracts is reported. A strong immunoreactivity for tissue kallikrein was observed in the seromucous glands of the nasal mucosa, trachea, and bronchi. In these glands, the immunostaining was restricted to the serous component of the acinus whereas mucous cells showed no staining. Since no immunoreactivity to kininogen was observed in any of the tissue constituents of the human and guinea-pig respiratory tree, transudation of the substrate from plasma was considered to be the preferred mode of delivery of the kininogen into the bronchopulmonary interstitium and lumen. Our results provide morphological evidence for the well documented presence of tissue kallikrein in bronchial lavage fluids and support the hypothesis that kinins may be one of the more important mediators involved during acute episodes of asthma and rhinitis. |
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