Abstract: | Nucleoside diphosphatkinase activity in mitochondria and post-mitochondrial supernatant fraction from brain and liver tissues was shown to decrease sharply during the first 60 min after total-body gamma-irradiation of rats with an absolutely lethal dose (30 Gy). A significant increase in the enzyme activity was registered 3 and 24 h following irradiation. Changes in nucleoside diphosphatkinase activity were more pronounced in mitochondria (particularly in liver mitochondria) than in the supernatant fraction. |