The contribution of tellurite resistance genes to the fitness of Escherichia coli uropathogenic strains |
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Authors: | Danka Valková Lenka Valkovi?ová Silvia Vávrová Elena Ková?ová Jozef Mravec Ján Turňa |
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Institution: | (1) Department of Molecular Biology, Faculty of Natural Sciences, Comenius University in Bratislava, 84215 Bratislava, Slovak Republic;(2) Institute of Virology, Slovak Academy of Sciences, 84245 Bratislava, Slovak Republic |
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Abstract: | The presence of tellurite resistance gene operons has been reported in several human pathogens despite the fact that tellurium,
as well as its soluble salts, are both rare in nature and are no longer in use as antimicrobial agents. We have introduced
the cloned terWZA-F genes from an uropathogenic Escherichia coli isolate into another clinical E. coli isolate that was shown to be ter-gene free. The presence of the introduced genes increased the level of potassium tellurite resistance, as well as the level
of resistance to oxidative stress mediated by hydrogen peroxide; and prolonged the ability of particular strains to survive
in macrophages. We therefore propose that the contribution of tellurite resistance genes to oxidative stress resistance in
bacteria is at least one reason for their presence in the genomes of a broad range of pathogenic microorganisms. |
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Keywords: | Tellurite resistance pathogenic Escherichia coli bacterial fitness |
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