Possible interaction of PGF2 alpha with hypothalamus-pituitary-thyroid axis in man

The possible interactions of PGF_{2 alpha} on the hypothalamus-pituitary-thyroid axis are the object of this study.Firstly a significant direct effect of PGF_{2 alpha} infusion (mg2, 5/270 min) on TSH,PRL,LH,FSH and GH pituitary secretion was excluded.Thereafter the possible PGF_{2 alpha} on PRL and TSH pituitary response to TRH was considered: in only two cases PGF_{2 alpha} was able to increase the TSH response.Finally the Authors studied T₃ response to endogenous TSH rise induced by TRH: if they consider the mean peak responses of T₃ the increase is significant only when PGF_{2 alpha} infusion is performed.