Interplay of cell proliferation and cell death in Drosophila tissue regeneration |
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Authors: | Soshiro Kashio Fumiaki Obata Masayuki Miura |
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Affiliation: | 1. Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, , Bunkyo‐ku, Tokyo, 113‐0033;2. CREST, Japan Science and Technology Agency, , Chiyoda‐ku, Tokyo, 102‐0075 Japan |
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Abstract: | Regeneration is a fascinating process that allows some organisms to reconstruct damaged tissues. In addition to the classical regeneration model of the Drosophila larval imaginal discs, the genetically induced tissue ablation model has promoted the understanding of molecular mechanisms underlying cell death, proliferation, and remodeling for tissue regeneration. Recent studies have also revealed that tissue injury responses occur not only locally but also systemically, even in the uninjured region. Genetic studies in Drosophila have demonstrated the dynamic role of the cell death‐induced tissue response in the reconstruction of damaged tissues. |
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Keywords: | cell death compensatory proliferation
Drosophila
imaginal disc regeneration |
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