Assignment of the gene for beta-spectrin (SPTB) to chromosome 14q23----q24.2 by in situ hybridization |
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| Authors: | Y Fukushima M G Byers P C Watkins J C Winkelmann B G Forget T B Shows |
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| Institution: | Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo 14263. |
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| Abstract: | Type I hereditary spherocytosis results from a molecular defect in the beta-polypeptide of the erythrocyte cytoskeletal protein spectrin. Using a cDNA probe, we had previously assigned the gene for human erythrocyte beta-spectrin (SPTB) to chromosome 14 based upon analysis of its segregation in panels of human x rodent somatic cell hybrids (Winkelmann et al., 1988). Here we report the regional localization of this gene by in situ hybridization to 14q23----q24.2. |
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