| Structural Features of Human Memapsin 2 （β-Secretase） and Their Biological and Pathological Implications |
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| 作者姓名： | Hong L He X Huang X Chang W Tang J |
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| 作者单位： | Protein Studies |
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| 基金项目： | This work was supported by a grant from NIH (No. AG-18933) and an Alzheimer’s Association Pioneer Award to Prof. Jordan TANG |
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| 摘 要： | Alzheimer’s disease (AD), which is characterized bythe progressive destruction of brain functions in olderpeople, was first recognized in the early 20th century.Since then, modern medicine has further increased thenumber of people living to old age. AD h…
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| 关 键 词： | memapsin 2 β-secretase Alzheimer’s disease β-amyloid β-amyloid precursor protein aspartic protease endocytosis cellular trafficking. |
Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications |
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| Hong L,He X,Huang X,Chang W,Tang J.Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications[J].Acta Biochimica et Biophysica Sinica,2004,36(12):787-792. |
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| Authors: | Hong Lin He Xiangyuan Huang Xiangping Chang Wanpin Tang Jordan |
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| Institution: | Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA. |
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| Abstract: | Memapsin 2 (beta-secretase) is the membrane-anchored aspartic protease that initiates the cleavage of beta-amyloid precursor protein (APP) leading to the production of amyloid-beta (Abeta), a major factor in the pathogenesis of Alzheimer's disease (AD). Since memapsin 2 is a major target for the development of inhibitor drugs for AD, it has been intensively studied during the past five years. Here we discuss the structural features of the catalytic/specificity apparatus, transmembrane domain, cytosolic domain and the implications of these features in the physiological and pathological roles of this protease. |
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