Notch Signalling: Receptor cis-Inhibition To Achieve Directionality |
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Authors: | David del lamo,Fran ois Schweisguth |
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Affiliation: | aInstitut Pasteur, CNRS URA2578, 25 rue du Dr. Roux, 75724 Paris CEDEX 15, France |
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Abstract: | Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells. New evidence suggests that cis-inhibition of the receptor in the ligand-sending cell might also provide directionality. |
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