A method for estimating rates of nucleotide substitution using DNA sequence data |
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Authors: | N Kaplan K Risko |
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Institution: | National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 U.S.A. |
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Abstract: | An estimate of the average number of evolutionarily acceptable substitutions per nucleotide since the most recent common ancestor of a pair of homologous sequences is found which uses nucleotide sequence data. The estimate is derived assuming a Poisson-like model for the evolutionary process. A method is also suggested for analyzing nucleotide sequence data in M homologous sequences (M 3). A simulation study is reported showing that the estimates are satisfactory providing there is sufficient homology between the sequences. To demonstrate the methods a numerical example using some β-globin data is presented. |
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