Genome-wide profiling of gene expression in the epididymis of alpha-chlorohydrin-induced infertile rats using an oligonucleotide microarray |
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| Authors: | Shuwu Xie Yan Zhu Li Ma Yingying Lu Jieyun Zhou Youlun Gui Lin Cao |
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| Affiliation: | (1) Department of Reproductive Pharmacology, Shanghai Institute of Planned Parenthood Research, Shanghai, 200032, China;(2) National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai, 200030, China;(3) Department of Cancer and Cell Biology, the Vontz Center for Molecular Study, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH, USA;(4) Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, China |
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| Abstract: | Background As one of the chlorinated antifertility compounds, alpha-chlorohydrin (ACH) can inhibit glyceraldehyde-3-phosphate dehydrogenase (G3PDH) activity in epididymal sperm and affect sperm energy metabolism, maturation and fertilization, eventually leading to male infertility. Further studies demonstrated that the inhibitory effect of ACH on G3PDH is not only confined to epididymal sperm but also to the epididymis. Moreover, little investigation on gene expression changes in the epididymis after ACH treatment has been conducted. Therefore, gene expression studies may indicate new epididymal targets related to sperm maturation and fertility through the analysis of ACH-treated infertile animals. |
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