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Microautophagy of cytosolic proteins by late endosomes
Authors:Sahu Ranjit  Kaushik Susmita  Clement Cristina C  Cannizzo Elvira S  Scharf Brian  Follenzi Antonia  Potolicchio Ilaria  Nieves Edward  Cuervo Ana Maria  Santambrogio Laura
Institution:Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abstract:
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  • Highlights? Late endosomes take up cytosolic proteins through membrane invaginations ? Endosomal microautophagy (eMI) requires multivesicular body formation ? hsc70 mediates selective targeting of cytosolic proteins during eMI ? hsc70 binds to the endosomal membrane through its polybasic cluster
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