The high mobility group I-C gene (HMGI-C): polymorphism and genetic localization |
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| Authors: | C S Ishwad M D Shriver D M Lassige R E Ferrell |
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| Institution: | (1) Department of Human Genetics, Graduate School of Public Health, 130 De Soto Street, University of Pittsburgh, PA 15261, USA Tel.: + 1-412-624-3018; Fax: +1-412-624-3020, US |
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| Abstract: | We have identified a highly informative dinucleotide repeat in the 5′-flanking region of the human high mobility group I-C
(HMGI-C) gene. This polymorphism consists of 18–37 copies of a (CT) repeat with an observed heterozygosity of 82–83% in African
Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13–15 with
no recombination observed between HMCI-C and markers D12S102 and D12S8.
Received: 16 February 1996 / Revised: 30 April 1996, 29 July 1996 |
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