| Noradrenaline as a putative neurotransmitter mediating hypotension—induced FOs—like immunoreactivity in the supraoptic nucleus of the rat |
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| 引用本文： | SHENEH XIASUN. Noradrenaline as a putative neurotransmitter mediating hypotension—induced FOs—like immunoreactivity in the supraoptic nucleus of the rat[J]. Cell research, 1995, 5(2): 209-220 |
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| 作者姓名： | SHENEH XIASUN |
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| 作者单位： | [1]ShanghaiBrainResearchInstitute,ChineseAcademyofSciences,Shanghai20031,China [2]ShanghaiBrainResearchInst,ChineseAcademyofSciences,Shanghai20031,China |
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| 摘 要： | Hemorrhage or hypotension induces extensive Fos-like immunoreactivity in the magnocellular neurosecretory cells in the supraoptic nucleus of the hypothalamus in rat,especially in the vasopressin neurons.The present study was to explore the neurotransmitter mediating this effect,Microinfusion of the alpha-adrenergic blocker into the supraoptic nucleus reduced the hypotension-induced FOs.whereas beta-antagonist did not affect it significantly.Alaha1-and alpha2-antagonist,prazosin and yohimbine,both reduced the Fos-Positive cell counts.However,the effective dosage of yohimbine was much larger,Alpha1-agonist,methoxamine,induced abundant Fos-like immunoreactivity in the vasopressin cells in this nucleus,while beta-and alpha2-agonist did not elicit such effect.Administration of the noradrenergic re-uptake inhibitor desipramine,to this nucleus to locally accumulate the spontaneously released noradrenaline from the nerve terminals also induced Fos expression,mostly in the vasopressin cells.
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| 关 键 词： | 丘脑下部 大鼠 视上核 C－fos 神经分泌细胞 低血压诱导Fos样免疫反应性 去甲肾上腺素 神经递质 介导 血管紧张素 |
Noradrenaline as a putative neurotransmitter mediating hypotension-induced Fos-like immunoreactivity in the supraoptic nucleus of the rat |
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| SHEN EH, XIA SUN. Noradrenaline as a putative neurotransmitter mediating hypotension-induced Fos-like immunoreactivity in the supraoptic nucleus of the rat[J]. Cell research, 1995, 5(2): 209-220 |
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| Authors: | SHEN EH XIA SUN |
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| Abstract: | Hemorrhage or hypotension induces extensive Foslike immunoreactivity in the magnocellular neurosecretory cells in the supraoptic nucleus of the hypothalamus in rat, especially in the vasopressin neurons. The present study was to explore the neurotransmitter mediating this effect. Microinfusion of the alpha-adrenergic blocker into the supraoptic nucleus reduced the hypotension-induced Fos, whereas beta-antagonist did not affect it significantly. Alpha1- and alpha2-antagonist, prazosin and yohimbine,both reduced the Fos-positive cell counts. However, the effective dosage of yohimbine was much larger. Alpha1-agonist, methoxamine, induced abundant Fos-like immnnoreactivity in the vasopressin cells in this nucleus,while beta-and alpha2-agonist did not elicit such effect.Administration of the noradrenergic re-uptake inhibitor,desipramine, to this nucleus to locally accumulate the spontaneously released noradrenaline from the nerve terminals also induced Fos expression, mostly in the vasopressin cells. |
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| Keywords: | c-fos neurosecretory cells noradrenaline supraoptic nucleus vasopressin |
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