DNA binding activity of the BarH1 homeodomain of Drosophila. |
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| Authors: | H Akimaru K Saigo |
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| Affiliation: | Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan. |
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| Abstract: | Using a series of deletion mutants of BarH1, a Drosophila homeobox gene required for eye morphogenesis, the DNA-binding region of the BarH1 protein was determined. Not only homeodomain but also its upstream sequence were found to be necessary for binding, whereas about a half of the conserved downstream sequence (Bar domain) was dispensable. |
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