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Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family |
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| Authors: | Jeremy D Glasner Thomas D Kocher John J Collins |
| Institution: | (1) Program in Genetics, University of New Hampshire, 03824 Durham, NH, USA;(2) Department of Zoology, University of New Hampshire, 03824 Durham, NH, USA;(3) Department of Biochemistry and Molecular Biology, University of New Hampshire, 03824 Durham, NH, USA |
| Abstract: | We have characterized two cDNA clones from the nematode Caenorhabditis elegans that display similarity to the alcohol dehydrogenase (ADH) gene family. The nucleotide sequences of these cDNAs predict that they encode Zn-containing long-chain ADH enzymes. Phylogenetic analysis suggests that one is most similar to dimeric class III ADHs found in diverse taxa; the other is most similar to the tetrameric forms of ADH previously described only in fungi. Correspondence to: J.J. Collins |
| Keywords: | Alcohol dehydrogenase Caenorhabditis elegans Evolution Gene families |
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