Salt water promotes hypertension in Dahl-S rats. |
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| Authors: | N Miura S Suzuki Y Hamada R Kamimura M Fujiki K Misumi H Sakamoto |
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| Institution: | Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Japan. |
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| Abstract: | Hypertension was induced in Dahl-salt-sensitive (Dahl-S) rats by administering salt in drinking water. Control rats receiving tap water did not show a significant change in blood pressure or abnormalities in the kidney. Rats receiving 0.5% NaCl solution developed moderate hypertension and renal lesions. Rats receiving 1.0% NaCl solution showed prominent and increasing hypertension and severe renal damage. This method of salt administration should be simpler than administration in the diet as a means of promoting renal hypertension. The lower concentration salt water caused chronic mild hypertension in Dahl-S rats, and may serve as a useful model for progressive hypertension. |
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