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Curcumin inhibits the metastasis of K1 papillary thyroid cancer cells via modulating E-cadherin and matrix metalloproteinase-9 expression |
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| Authors: | Chi-Yu Zhang Li Zhang Hui-Xin Yu Jian-Dong Bao Rong-Rong Lu |
| Affiliation: | 1. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China 2. Jiangsu Institute of Nuclear Medicine, Key Laboratory of Nuclear Medicine, Ministry of Health, 20 Qian Rong Road, Wuxi, 214063, Jiangsu, China |
| Abstract: | The anti-metastatic effect of curcumin on papillary thyroid cancer K1 cells and its underlying mechanisms were investigated. Curcumin at 12.5, 25 and 50 μM promoted mesenchymal–epithelial transition and decreased the migration rate of K1 cells by 24–87 %. Its mechanism may involve the up-regulation of E-cadherin expression levels and down-regulation of the activity and expression of matrix metalloproteinase-9. |
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