Model investigation of central regulatory contour of gene net of <Emphasis Type="Italic">D. melanogaster</Emphasis> macrochaete morphogenesis |
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Authors: | T A Bukharina V P Golubyatnikov I V Golubyatnikov D P Furman |
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Institution: | 1.Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russia;2.Sobolev Institute of Mathematics, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russia;3.Novosibirsk State University,Novosibirsk,Russia |
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Abstract: | Morphogenesis of drosophila macrochaete functioning as mechanoreceptors includes several steps, each of which has their own
genetic support described in terms of gene nets. Mechanoreceptor develops from one parental cell (Sensory Organ Precursor
cell—SOP cell), the determination of which has a critical role in macrochaete development. The highest content of AS-C proneural
proteins with respect to surrounding cells that initiate a neural way of cellular development and by means of it mechanoreceptor
morphogenesis is typical for SOP cell. The key object of gene net providing parental cell determination consists of gene complex
achaete-scute (AS-C). This complex activity is controlled by central regulatory contour (CRC). Besides AS-C, CRC includes the following genes: hairy, senseless (sens), charlatan (chn), scratch (scrt), daughterless (da), extramacrochaete (emc), and groucho (gro). The system of direct relation and feedback and induction and repression relations between CRC components are realized via
the coding by these genes proteins. A mathematical model of CRC functioning as a regulator of proneural AS-C protein content
in SOP cell determining successful passing of the main phase of morphogenesis of D. melanogaster mechanoreceptor is discussed. |
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