山楂降脂汤对高脂血症大鼠血脂水平的调节和血管内皮保护作用

目的观察山楂降脂汤对高脂血症大鼠血脂水平调节和血管内皮的保护作用,以及对肝组织的影响。方法采用高脂饲料饲喂法建立高脂血症大鼠模型,通过山楂降脂汤高、中、低剂量和阳性对照药血脂康分别灌胃,观察大鼠的一般情况及肝、肾组织的病理变化,检测大鼠丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆固醇（TCHO）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、一氧化氮（NO）和内皮素-1（ET-1）的含量。结果山楂降脂汤高、中、低剂量均能显著降低模型大鼠血液ALT、AST、UA、TCHO、TC、LDL-C、ET-1含量（P〈0.05,P〈0.01）,提高HDL-C、NO含量（P〈0.05,P〈0.01）,其中山楂降脂汤的作用随剂量递增。结论山楂降脂汤能显著调节机体的血脂水平,有效预防高脂血症和保护血管内皮细胞功能。

Regulation of Serum Lipid Level by SHANZHAJIANGZHI Decoction and Its Protective Effect on Vascular Endothelium in Hyperlipidemic Rats

Objective To study the regulation of serum lipid level by a Chinese medicine, SHANZHAJIANGZHI decoction,and its protective effect on vascular endothelial cells, as well the influence on liver tissue in hyperlipidemic rats. Methods To establish a rat model of hyperlipidemia by feeding high-lipid diet. SHANZHAJIANGZHI decoction （SZJZD） and Xuezhikang were intragastically given to the rats for 35 days. The levels of ALT, AST, TCHO, TG, HDL-C, LDL-C, and the contents of ET-1 and NO in file rat blood were measured. The general condition of rats was observed and morphological changes of the hver and kidney were examined by histopathology. Resluts SZJZD significantly reduced TCHO, TC, LDL-C, TCHO and ET-1 while increased HDL-C and NO （ P 〈 0.05, P 〈 0.01 ）, and the effects were in a dose-dependent manner. Conclusion SZ./ZD can effectively regulate the serum lipid level, prevent hyperlipidemia, and show a protective effect on vascular endothelial cells.