| 不同月龄p21^HBsAg/HBsAg和p21^HBX/HBX转基因小鼠血清酶含量的测定 |
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| 引用本文： | 王冬平,孙岩松,尚书江,吴娜,隋丽华,尚世臣,杨晓,李慕,孔德强,李桂军,凡秀,张爱兰. 不同月龄p21^HBsAg/HBsAg和p21^HBX/HBX转基因小鼠血清酶含量的测定[J]. 中国实验动物学杂志, 2009, 0(1): 11-14 |
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| 作者姓名： | 王冬平 孙岩松 尚书江 吴娜 隋丽华 尚世臣 杨晓 李慕 孔德强 李桂军 凡秀 张爱兰 |
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| 作者单位： | [1]军事医学科学院实验动物中心,北京100072 [2]军事医学科学院生物工程研究所发育和疾病遗传学研究室,北京100071 |
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| 基金项目： | 863课题2002BA711A02-5. |
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| 摘 要： | 目的测定p21^HBsAg/HBsAg和p21^HBX/HBX转基因小鼠纯合型及野生型小鼠的血清酶,探讨各种血清酶在两种纯合型小鼠及野生型小鼠的变化规律。方法采用荷兰半自动生化分析仪Ⅱ对于肝功能相关的7种血清酶进行测定,应用SSPS10统计学软件进行T检验及方差分析比较。结果p2^1HBsAg/HBsAg和p21^HBX/HBX转基因小鼠不同年龄、不同的指标雌雄之间差异显著,并且随着年龄的变化,雌雄之间的变化规律不同。结论p21^HBsAg/HBsAg和p21^HBX/HBX转基因小鼠的血清酶在不同的年龄具有一定的变化规律,说明p21^HBsAg/HBsAg和p21^HBX/HBX转基因小鼠的血清酶具有一定的特征,为其功能性研究及临床检验具有重要参考价值。
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| 关 键 词： | p21HBsAg/HBsAg转基因小鼠 p21HBX/HBX转基因小鼠 血清酶 |
Determination of Seroenzyme Activity of p 21^HBsAg/HbsAg and p 21^HBX/HBX Transgenic Mice on the Different Age |
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| WANG Dong-ping,SUN Yah-song,SHANG Shu-jiang,WU Na,SUI Li-hua,SHANG Shi-chen,YANG Xiao,LI Mu,KONG De-qiang,LI Gui-jun,FAN Xiu,ZHANG Ai-lan. Determination of Seroenzyme Activity of p 21^HBsAg/HbsAg and p 21^HBX/HBX Transgenic Mice on the Different Age[J]. Chinese Journal of Laboratory Animal Science, 2009, 0(1): 11-14 |
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| Authors: | WANG Dong-ping SUN Yah-song SHANG Shu-jiang WU Na SUI Li-hua SHANG Shi-chen YANG Xiao LI Mu KONG De-qiang LI Gui-jun FAN Xiu ZHANG Ai-lan |
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| Affiliation: | 1. Laboratory Animal Center, Academy Of Medical Sciences, Beijing 10071, China; 2. Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing 10071, China) |
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| Abstract: | Objective To obtain the basic data of seroenzyme activity of p 21^HBsAg/HbsAg and p 21^HBX/HBX transgenic mice on the different age, and To study the infection of the seroenzyme activity, of the p 21^HBsAg/HbsAg and p 21^HBX/HBX was introduced into p21 locus of the mouse. Methods The seroenzyme activity of seven strain were deteminated in different age of p 21^HBsAg/HbsAg and p 21^HBX/HBX transgenic mice for ViTALAB made in Holland. To compare T-test and Analysis of Variance for SSPS10. Results There were a lot significant differences in mice between sexes（male and female mice） and ages. There are significant differences on the seroenzyme activity of the p 21^HBsAg/HbsAg and p 21^HBX/HBX transgenic mice and Wild-types. Conclusion there are infection on some seroenzyme activity of the p 21^HBsAg/HbsAg and p 21^HBX/HBX was introduced into p21 locus of the mouse. The activities of the seroenzymes have been changed due to the p 21^HBsAg/HbsAg and p 21^HBX/HBX was introduced into p21 locus of the mouse. |
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| Keywords: | p21^HBAg/HBsAg transgenic mice p21^HBX/HBX transgenic mice, Seroenzyme activity |
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