| 肾大部切除大鼠肾衰模型制备方法 |
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| 引用本文： | 潘卉萱,程骏章,姜鸿,刘建社.肾大部切除大鼠肾衰模型制备方法[J].中国实验动物学杂志,2009(5):70-71. |
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| 作者姓名： | 潘卉萱 程骏章 姜鸿 刘建社 |
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| 作者单位： | [1]长江大学临床医学院,荆州434000 [2]长江大学附属第一医院肾内科,荆州434000 [3]华中科技大学医学院附属协和医院肾内科,武汉430022 |
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| 摘 要： | 目的探讨一次手术建立大鼠肾大部切除肾衰模型的可行性。方法取雄性SD大鼠40只随机平均分为两组构建大鼠肾大部切除肾衰模型,A组采用传统的两次手术造模,B组采用改良的一次手术的方法;比较两组模型的死亡率、成功率。结果两组间各指标无统计学差异（P〉0.05）。结论一次手术建立大鼠肾大部切除肾衰模型是简便易行,是值得推荐的一种肾大部切除术式。
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| 关 键 词： | 肾大部切除 术式 慢性肾衰竭 大鼠 |
Method of Making Chronic Renal Failure Rat Modles with Kidney Subtotal Excision |
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| PAN Hui-xuan,CHEN Jun-zhang,JIANG Hong,LIU Jian-she.Method of Making Chronic Renal Failure Rat Modles with Kidney Subtotal Excision[J].Chinese Journal of Laboratory Animal Science,2009(5):70-71. |
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| Authors: | PAN Hui-xuan CHEN Jun-zhang JIANG Hong LIU Jian-she |
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| Institution: | 1. Yangtze University Clinic Medical College, Jingzhou,434000, China ; 2. First Affiliated Hospital, Yangtze University, Jingzhou,434000, China; 3. Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China) |
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| Abstract: | Objective To verify the feasibility of establishing an animal model of chronic renal failure induced by subtotal nephrectomy with one-step operation in rats. Methods 40 Male SD rats were divided into operation group and control group randomly. Control group was subject to two-step operation and operation group was subject to one-step operation. The mortality and operation success ratio between the two groups were compared. Results All the indexes compared are non-statistics difference between the two groups （ P 〉 0.05）. Conclusion Animal model of chronic renal failure was carried out successfully by one-step operation, which was easy to carry out. |
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| Keywords: | Kidney subtotal excision Surgery methods Chronic renal failure Rat |
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