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Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis |
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| Authors: | Hong-Hee Choi Dong-Min Shin Gun Kang Jin Bong Park Gang Min Hur Hye-Mi Lee Yun-Ji Lim Eun-Kyeong Jo Chang-Hwa Song |
| Institution: | a Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301-747, South Korea b Department of Physiology, College of Medicine, Chungnam National University, Daejeon 301-747, South Korea c Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 301-747, South Korea d Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon 301-747, South Korea e Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon 301-747, South Korea |
| Abstract: | Mycobacterium tuberculosis (Mtb) infection leads to the induction of the apoptotic response, which is associated with bacilli killing. The early secreted mycobacterial antigen ESAT-6 of Mtb has been shown to induce apoptosis in human macrophages and epithelial cells. In the present study, we demonstrate that the stimulation of human epithelial A549 cells by ESAT-6 induces the endoplasmic reticulum (ER) stress response. We observed that ESAT-6 treatment increases intracellular Ca2+ concentration, which results in ROS accumulation, and therefore induces the onset of ER stress-induced apoptosis. Our results uncover a novel apoptotic mechanism of ESAT-6 through ER stress responses in pathologic conditions such as tuberculosis. |
| Keywords: | Infection Endoplasmic reticulum stress |
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