Beyond ribosome rescue: tmRNA and co-translational processes |
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Authors: | Christopher S Hayes |
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Institution: | a Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106-9610, USA b Department of Biochemistry and Molecular Biology, 401 Althouse Laboratory, The Pennsylvania State University, University Park, PA 16802, USA |
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Abstract: | tmRNA is a unique bi-functional RNA that acts as both a tRNA and an mRNA to enter stalled ribosomes and direct the addition of a peptide tag to the C terminus of nascent polypeptides. Despite a reasonably clear understanding of tmRNA activity, the reason for its absolute conservation throughout the eubacteria is unknown. Although tmRNA plays many physiological roles in different bacterial systems, recent studies suggest a general role for trans-translation in monitoring protein folding and perhaps other co-translational processes. This review will focus on these new hypotheses and the data that support them. |
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Keywords: | Ribosome pausing SmpB tmRNA Translation trans-Translation |
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