Functional interactions by transfer RNAs in the ribosome |
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Authors: | Prashant Khade |
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Affiliation: | Department of Chemistry and Biochemistry, University of California, 4102 Urey Hall, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0314, United States |
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Abstract: | Recent X-ray crystal structures of the ribosome have revolutionized the field by providing a much-needed structural framework to understand ribosome function. Indeed, the crystal structures rationalize much of the genetic and biochemical data that have been meticulously gathered over 50 years. Here, we focus on the interactions between tRNAs and the ribosome and describe some of the insights that the structures provide about the mechanism of translation. Both high-resolution structures and functional studies are essential for fully appreciating the complex process of protein synthesis. |
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Keywords: | ASL, anticodon stem-loop analog of tRNA IF, initiation factor EF-Tu, elongation factor Tu EF-G, elongation factor G RF, release factor RRF, ribosome recycling factor |
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