Membrane microdomains and insulin resistance |
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| Authors: | Jin-ichi Inokuchi |
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| Affiliation: | Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Miyagi, Japan |
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| Abstract: | A new concept, that “metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides”, has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in microdomains and propose the new therapeutic strategy “membrane microdomain ortho-signaling therapy”. |
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| Keywords: | DRM, detergent resistant membrane microdomains Cav1, caveolin-1 IR, insulin receptor IRS, insulin receptor substrate SAT-I, GM3 synthase FRAP, fluorescence recovery after photobleeching GEM, glycosphingolipid-enriched microdomains |
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