Voltage-dependent anion-selective channel (VDAC) in the plasma membrane |
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| Authors: | Vito De Pinto Angela Messina Alfons Lawen |
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| Institution: | a Department of Chemical Sciences, University of Catania, Istituto Nazionale di Biomembrane e Biosistemi, Sezione di Catania, viale A. Doria 6, 95125 Catania, Italy
b Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University VIC3800, Australia |
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| Abstract: | Voltage-dependent anion channels (VDACs) have originally been characterized as mitochondrial porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs can also be expressed in plasma membranes. In this review, we briefly revisit the historical milestones in the discovery of plasma membrane-bound VDAC, and we critically analyze the evidence for VDAC plasma membrane localization obtained from various purification strategies and recently from plasma membrane proteomics studies. We discuss the possible biological function and relevance of VDAC in the plasma membrane and finally discuss a hypothetical model of how VDAC may be targeted to the plasma membrane. |
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| Keywords: | ER endoplasmic reticulum HTP hydroxylapatite MAMs mitochondria-associated membranes OMM outer mitochondrial membrane PAMs plasma membrane/ER associations TOB topogenesis of β-barrel membrane proteins TOM translocase of the outer membrane VDAC voltage dependent anion-selective channel |
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