Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1 |
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| Authors: | Madeleine Herrmann Klemens Ruprecht Marlies Sauter Pearl van Heteren Barbara Best Klaus Roemer |
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| Affiliation: | a Institute of Virology, Building 47, University of Saarland Medical School, 66421 Homburg (Saar), Germany
b José-Carreras Center, Building 45.3, University of Saarland Medical School, 66421 Homburg (Saar), Germany |
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| Abstract: | Retrovirus replication critically depends on a dynamic interplay between retroviral and host proteins. We report on the binding of the surface subunit (glycoprotein 120 (gp120)) of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) to the cytoplasmic C-terminus of the voltage-gated potassium channel BEC1 (brain-specific ether-a-go-go-like channel 1), an interaction that can result in the repression of BEC’s activity and the inhibition of HIV-1 particle-release. BEC1 protein was found to be expressed in T cells and macrophages, the major target cells of HIV-1. Thus, gp120/BEC1 interaction may be involved in HIV-1 life cycle and/or pathogenesis.Structured summaryMINT-7968695: BEC1 (uniprotkb:Q9ULD8) physically interacts (MI:0915) with gp160 (uniprotkb:P04578) by anti bait coimmunoprecipitation (MI:0006)MINT-7968714: BEC1 (uniprotkb:Q9ULD8) physically interacts (MI:0915) with gp160 (uniprotkb:P04578) by anti tag coimmunoprecipitation (MI:0007)MINT-7968675: BEC1 (uniprotkb:Q9ULD8) physically interacts (MI:0915) with gp160 (uniprotkb:P04578) by pull down (MI:0096) |
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| Keywords: | Human immunodeficiency virus Immunodeficiency virus Glycoprotein 120 Potassium channel |
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