Trichinella spiralis: Immune response and protective immunity elicited by recombinant paramyosin formulated with different adjuvants |
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| Authors: | Jing Yang Yaping Yang Shaohua Wang Jin Pan Xinping Zhu |
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| Affiliation: | a Department of Parasitology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, You An Men, Beijing 100069, PR China
b Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101100, PR China |
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| Abstract: | Our previous studies showed that immunization with recombinant paramyosin from Trichinella spiralis (rTs-Pmy) formulated with Freund’s adjuvant significantly reduced larval burden in mice after T. spiralis larval challenge. Since Freund’s adjuvant is toxic and not a suitable adjuvant for clinical vaccine trials, we evaluated the ability of the adjuvants Montanide ISA206 and ISA720 to stimulate immune responses during rTs-Pmy immunization and to enhance protective immunity. The results revealed that immunization of BALB/c mice with rTs-Pmy formulated with either ISA206 or ISA720 triggered Th1 and Th2 immune responses similar to those produced by the conventional Freund’s adjuvant formulation and also provided a similar level of protection against T. spiralis larval challenge. This indicates that the recombinant Ts-Pmy formulated with Montanide ISA206 or ISA720 may be an effective and safety vaccine strategy for trichinellosis. |
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| Keywords: | Trichinella spiralis Recombinant paramyosin (rTs-Pmy) Montanide ISA206 Montanide ISA720 |
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