Structural requirements of anthocyanins in relation to inhibition of endothelial injury induced by oxidized low-density lipoprotein and correlation with radical scavenging activity |
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Authors: | Long Yi Chun-ye Chen Xin Jin Bin Yu Wen-hua Ling |
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Institution: | a Research Center for Nutrition and Food safety, The Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing 400038, PR China b Department of Medical Nutriology, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, PR China |
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Abstract: | Anthocyanins may play an important role in atherosclerosis prevention. However, the structure-function relationships are not well understood. The objective of this study was to compare the inhibitory effect of 21 anthocyanins against oxidized low-density lipoprotein-induced endothelial injury to understand the relationship between anthocyanin chemical structure and the endothelial protective properties, measured as cell viability, MDA production and NO release. Additionally, the intracellular anti-radical activity of the selected anthocyanins was investigated to identify the correlation with endothelial protection. Our results provide evidence that the number of -OH in total or in B-ring, 3′,4′-ortho-dihydroxyl and 3-hydroxyl are the main structural requirements of anthocyanins in suppressing oxidative stress-induced endothelial injury and such inhibitory effect was significantly correlated with the intracellular radical scavenging activity. |
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Keywords: | Anthocyanin Endothelial cell Structure-activity relationship Oxidized low-density lipoprotein Atherosclerosis Antiradical activity |
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