Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice |
| |
Authors: | Bin Li Julie Blanchard Khalid Iqbal |
| |
Affiliation: | Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA |
| |
Abstract: | Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote neurogenesis and maturation of newborn cells into mature functional neurons represents an exciting therapeutic opportunity for treatment of Alzheimer disease and other learning and memory disorders as well as enhancing cognition of normal individuals. Here we report the design of a peptidergic compound, Ac-DGGLAG-NH2, called P21, when administered peripherally, enhanced learning as well as both short-term and spatial reference memories of normal adult C57Bl6 mice. P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus. |
| |
Keywords: | AD, Alzheimer disease BBB, blood-brain-barrier DG, dentate gyrus GCL, granule cell layer LIFR, leukemia inhibitory factor receptor MCL, molecular cell layer SPPS, solid phase peptide synthesis SGZ, subgranular zone |
本文献已被 ScienceDirect 等数据库收录! |
|