Comparative genomic and phylogenetic investigation of the xenobiotic metabolizing arylamine N-acetyltransferase enzyme family |
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| Authors: | Anthony E. Glenn Αntigona Ulndreaj |
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| Affiliation: | a Toxicology and Mycotoxin Research Unit, Russell Research Center, Agricultural Research Service, United States Department of Agriculture, 950 College Station Road, Athens, GA 30605, USA
b Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis 68100, Greece |
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| Abstract: | Arylamine N-acetyltransferases (NATs) are xenobiotic metabolizing enzymes characterized in several bacteria and eukaryotic organisms. We report a comprehensive phylogenetic analysis employing an exhaustive dataset of NAT-homologous sequences recovered through inspection of 2445 genomes. We describe the first NAT homologues in viruses, archaea, protists, many fungi and invertebrates, providing complete annotations in line with the consensus nomenclature. Contrary to the NAT genes of vertebrates, introns are commonly found within the homologous coding regions of lower eukaryotes. The NATs of fungi and higher animals are distinctly monophyletic, but evidence supports a mixed phylogeny of NATs among bacteria, protists and possibly some invertebrates. |
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| Keywords: | EMBL, European Molecular Biology Laboratory EST, expressed sequence tag HGT, horizontal gene transfer MP, maximum parsimony NAT, arylamine N-acetyltransferase NCBI, National Center for Biotechnology Information NJ, neighbor-joining ORF, open reading frame TPA, third-party annotation UTR, untranslated region |
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