The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport |
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Authors: | Cenk Suphioglu Damitha De Mel Nadia Sadli Agnes Michalczyk M Leigh Ackland |
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Institution: | a School of Life and Environmental Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia b School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia c School of Medicine, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia |
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Abstract: | Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid in neuronal cell membranes. We hypothesize that DHA induces a decrease in neuronal cell death through reduced ZnT3 expression and zinc uptake. Exposure of M17 cells to DHA-deficient medium increased the levels of active caspase-3, relative to levels in DHA-replete cells, confirming the adverse effects of DHA deficiency in promoting neuronal cell death. In DHA-treated M17 cells, zinc uptake was 65% less and ZnT3 mRNA and protein levels were reduced in comparison with DHA-depleted cells. We propose that the neuroprotective function of DHA is exerted through a reduction in cellular zinc levels that in turn inhibits apoptosis. |
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Keywords: | DHA Omega-3 fatty acid Zinc ZnT3 M17 human neuronal cell Apoptosis |
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