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Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways |
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| Authors: | Geoffrey Guittard,Eva Mortier,Guylè ne Firaguay,Audrey Gé rard,Pascale Zimmermann,Jacques A. Nunè s |
| Affiliation: | a Institut National de la Santé et de la Recherche Médicale, Unité 891, Centre de Recherche en Cancérologie de Marseille, F-13009 Marseille, France b Institut Paoli-Calmettes, F-13009 Marseille, France c Univ Méditerranée, F-13007 Marseille, France d Laboratory for Signal Integration in Cell Fate Decision, Department of Human Genetics, K.U. Leuven, B-3000 Leuven, Belgium e Inserm, Unité 563, CPTP, Département d’Oncogenèse, Signalisation et Innovation Thérapeutique, Université Toulouse III Paul Sabatier and Centre Hospitalier Universitaire de Toulouse F-31400, France |
| Abstract: | Phosphatidylinositol 5-phosphate (PtdIns5P) is emerging as a potential lipid messenger involved in several cell types, from plants to mammals. Expression of IpgD, a PtdIns(4, 5)P2 4-phosphatase induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a new PtdIns5P interacting domain blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering. Altogether, these data suggest that PtdIns5P may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis. |
| Keywords: | PIs, phosphoinositides PtdIns5P, phosphatidylinositol 5-phosphate IL-2, interleukin II TCR, T-cell receptor |
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